Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).
نویسندگان
چکیده
2. LNA: An Insight 4675 2.1. Family 4675 2.2. Synthesis 4676 2.3. Attributes 4677 2.3.1. Hybridization 4677 2.3.2. Thermodynamics 4677 2.3.3. Conformation 4680 2.3.4. Triplex-Forming Oligonucleotide (TFO) 4680 2.3.5. RNase H Activation 4681 2.3.6. Nuclease Resistance and Serum Stability 4682 2.3.7. Delivery into Cell 4683 2.3.8. In Vivo Toxicity 4683 3. LNA as a Tool: Implications 4684 3.1. LNA as a Therapeutic 4684 3.1.1. Antisense Agent 4684 3.1.2. Current Status: Clinical Trials 4688 3.1.3. Antigene Strategies 4688 3.2. LNA in Diagnostics 4689 3.2.1. Probes for Single Nucleotide Polymorphism (SNP) Detection 4689
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عنوان ژورنال:
- Chemical reviews
دوره 107 11 شماره
صفحات -
تاریخ انتشار 2007